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3-MeO-PCP (also known as 3-Methoxyphencyclidine) is a lnovel dissociative substance of the arylcyclohexylamine class. 3-Methoxyphencyclidine is a derivative of phencyclidine (PCP) and is chemically related to substances like methoxetamine and 3-MeO-PCE.Buy Alprazolam Powder online in USA

It produces its effects by blocking NMDA receptors in the brain.

Cas No: 91164-58-8
Formula: C18H27NO • HC1
IUPAC: 1-[1-(3-Methoxyphenyl)cyclohexyl]-piperidine

Phencyclidine (PCP) analogs, such as 3-methoxy PCP (3-MeO-PCP) and 4-methoxy PCP (4-MeO-PCP), are beginning to emerge that retain the dissociative anesthetic effects of the parent compound but are reported to have improved euphoric properties (1–3). Demand for these and other synthetic designer drugs appears to be increasing due to their ambiguous legal status and online availability (3–7). Synthetic recreational drugs are available for purchase under the guise of “research chemicals” (8), and many of these drugs are labeled “Not for human consumption”. Thus, synthetic drug analogs are being manufactured and distributed without a complete toxicological characterization. Although fatalities have been reported following PCP abuse, very few of these deaths have occurred in the absence of violent or accidental physical trauma (9). Because it is structurally similar to PCP, 3-MeO-PCP is a powerful N-methyl-D-aspartate (NMDA) receptor antagonist with a 3-fold higher binding affinity than native PCP (2). The affinity of 3-MeO-PCP for the NMDA receptor is one of the highest known, with a ki = 20 nM (2). Consequently, 3-MeO-PCP is expected to elicit effects similar to other NMDA antagonists. It can be administered through oral or parenteral routes, and activity is reported to begin at doses as low as 5 mg (1). As with PCP, low doses are associated with anxiety, muscle tremors, drowsiness and hallucinations (10), and higher doses have the potential to cause violent behavior, tachycardia, hyperthermia, suicidal impulses, seizure or coma (10, 11). At higher doses, individuals exposed to PCP may also experience pulmonary aspiration or cardiovascular collapse (11). Chronic use of PCP is associated with symptoms that resemble schizophrenia (12), to the extent that PCP administration has been used in research settings to model schizophrenia in rodents and primates (13). Although the medical ramifications of PCP abuse have been reported, toxicological information resulting from postmortem casework is lacking for the 3-MeO-PCP analog. Buy Alprazolam Powder online in USA Alprazolam Powder/

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